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Correlations Between the Autolytic Changes and Postmortem Interval in Refrigerated Cadavers.

Ela Andra Cocariu, V Mageriu, Florica Stăniceanu

    Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
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    This summary is machine-generated.

    Autolytic processes in organs are delayed and slow in cold morgue conditions. Different organs and locations within organs exhibit varying rates of cellular degradation postmortem.

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    Area of Science:

    • Forensic Pathology
    • Histology
    • Postmortem Interval Determination

    Background:

    • Autolysis is crucial for determining postmortem interval in forensic pathology.
    • Previous studies observed autolysis under various environmental conditions.

    Purpose of the Study:

    • To investigate autolytic changes in organs stored in a mortuary refrigerator.
    • To correlate these changes with the postmortem interval.

    Main Methods:

    • Microscopic examination of hematoxylin and eosin (HE) stained organ sections from 30 autopsied bodies.
    • Analysis of tissue and cell structure modifications.
    • Correlation with storage time in refrigeration (24 hours to 22 days).

    Main Results:

    • Severe autolytic alterations observed in lung, heart, liver, and pancreas after 5-8 days.
    • Pancreas showed the most rapid autolysis, with complete islet cell autolysis at 36 hours.
    • Autolysis rates varied within organs; subendocardial myocardium showed less degradation than subepicardial myocardium after 4 days.

    Conclusions:

    • Cold, controlled environments significantly delay the onset and slow the progression of autolysis.
    • Organ structure and enzymatic content influence the rate of autolytic degradation.