MRI in the synchronic chemoradiotherapy of cervical squamous cell carcinoma

This study aimed to explore the predictive value of the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in evaluating the therapeutic effects of synchronic chemoradiotherapy of cervical squamous cell carcinoma by using the functional imaging of 1.5T MR.

Fifty patients with cervical squamous cell carcinoma receiving synchronic chemoradiotherapy in the present hospital from October 2010 to February 2014 were enrolled in this study. MRI examination was performed on each patient before and after chemoradiotherapy. Eleven patients received an additional MRI examination when the in vitro cumulative radiation dose reached 36 Gy. The mean tumor ADC values of DWI sequence were measured before, under, and after chemoradiotherapy. At the end of the treatment, patients were divided into complete remission (CR) and partial remission (PR) groups on the basis of the residual tumors. Then the tumor ADC values and their changes before and after the treatment were analyzed using independent sample t-test.

At the end of the treatment, 32 patients achieved CR and 18 patients achieved PR. The tumor ADC values increased gradually with the treatment, showing significant difference between before, under, and after the treatment (p < 0.01). The mean tumor ADC values were remarkably higher in CR group than in PR group (p < 0.001).

The ADC values of MR functional imaging DWI can reflect the hydrone diffusion movement of tumor after the treatment, so that it is able to identify CR and PR in the patients, providing a new way and method for evaluating the therapeutic effects of cervical squamous cell carcinoma.