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Antidiabetic Mechanisms of Rosa canina Fruits: An In Vitro Evaluation

Ali Fattahi1,2, Fatemeh Niyazi3, Behzad Shahbazi1

  • 1Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Journal of Evidence-Based Complementary & Alternative Medicine
|June 30, 2016
PubMed

Insights

Rosa canina extract shows potential in managing diabetes mellitus by acting as a growth factor for pancreatic beta cells. This study explored its in vitro mechanisms, revealing a novel pathway for its antidiabetic effects.

Area of Science:

  • Pharmacology
  • Cell Biology
  • Natural Products

Background:

  • Traditional use of Rosa canina for diabetes treatment.
  • Need to elucidate the in vitro mechanism of action for its antidiabetic effects.

Purpose of the Study:

  • Evaluate the in vitro mechanism of action of Rosa canina in managing diabetes mellitus.
  • Investigate its effects on pancreatic beta cells and glucose metabolism.

Main Methods:

  • Cell proliferation and cytotoxicity assays on pancreatic beta-cell line (βTC6).
  • Assessment of protective activity against streptozotocin-induced cell death.
  • Evaluation of glucose metabolism in HepG2 cells and glucose diffusion across a dialysis membrane.

Main Results:

  • Rosa canina extract demonstrated a growth-promoting effect on pancreatic beta-cell line (βTC6).
  • The extract showed protective activity in a model of beta-cell death.
  • Effects on glucose metabolism and diffusion were observed, suggesting an impact on glucose uptake.

Conclusions:

  • Rosa canina extract acts as a growth factor for pancreatic beta cells, presenting a novel antidiabetic mechanism.
  • Further preclinical research is warranted to fully understand its therapeutic potential in diabetes mellitus.
Keywords:
Rosa caninacell proliferationdiabetes mellitustraditional medicine

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