Related Experiment Video

Updated: Mar 18, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.1K

Evidence of left atrial remodeling and left ventricular diastolic dysfunction in type 2 diabetes mellitus with

G Zoppini1, S Bonapace2, C Bergamini3

  • 1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|June 30, 2016
PubMed

Insights

Longer duration of type 2 diabetes is linked to increased left atrial volume index (LAVI) in men. This finding suggests diabetes duration impacts heart health, specifically left atrial size, in patients with type 2 diabetes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Cardiovascular disease (CVD) is a major complication and predictor of poor prognosis in type 2 diabetes (T2D).
  • Left atrial (LA) size is an established outcome predictor in various conditions, including diabetes.
  • The relationship between LA size and diabetes duration remains under-investigated.

Purpose of the Study:

  • To investigate the association between left atrial volume index (LAVI) and the duration of type 2 diabetes.
  • To test the hypothesis that LA volume increases with longer diabetes duration.

Main Methods:

  • Cross-sectional study involving 44 newly diagnosed and 172 established male T2D patients.
  • Transthoracic echocardiographic Doppler evaluation for all participants.
  • Multivariable analysis adjusted for age, HbA1c, hypertension, microvascular complications, and cardiac function parameters.

Main Results:

  • 28.2% of patients exhibited increased LAVI.
  • Lower diastolic and systolic function indices were observed in patients with larger LA.
  • LAVI values increased across diabetes duration categories, with longer duration predicting LAVI ≥34 ml/m² (OR 1.65, p=0.014).

Conclusions:

  • Diabetes duration is a significant positive predictor of increased LAVI in men with T2D and preserved systolic function.
  • Further research is required to understand the biological mechanisms linking T2D duration to elevated LAVI.
Abstract

Keywords:
Diabetes durationLAVITransthoracic echocardiographyType 2 diabetes

More Related Videos

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.7K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
725
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
819
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
393
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
885
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
636