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Updated: Mar 18, 2026
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Update on medical treatment of small intestinal neuroendocrine tumors
Sara Pusceddu1, Daniela Femia1, Giuseppe Lo Russo1
1a Department of Medical Oncology , Fondazione IRCCS 'Istituto Nazionale dei Tumori' , Milan , Italy.
Introduction:
Small intestinal (SI) neuroendocrine tumors (NETs) are relatively rare tumors. Due to the lack of symptom or specific symptoms, SI-NETs are often diagnosed at an advanced stage, making therapy challenging. The management of patients with advanced stage SI-NETS requires a multidisciplinary approach that combines surgical and medical treatment including novel targeted molecular therapies.
Areas Covered:
This article summarizes current strategies for the medical treatment of SI-NETS. Expert commentary: The treatment plan of advanced-stage SI-NETs should be tailored in a case-by-case manner with the adoption of a multidisciplinary approach that combines different treatment options, including biological targeted therapies. In particular, we believe that the identification of the optimal treatment sequence(s), correct treatment timing and the selection of patients eligible to different treatments need specific investigation in controlled clinical trials.
Insights
Small intestinal neuroendocrine tumors (SI-NETs) are often diagnosed late. Advanced SI-NET treatment requires a multidisciplinary approach combining surgery, medical therapies, and targeted molecular treatments.
Area of Science:
- Oncology
- Gastroenterology
- Medical Therapeutics
Background:
- Small intestinal neuroendocrine tumors (SI-NETs) are rare.
- Late diagnosis is common due to nonspecific symptoms.
- Advanced stage SI-NETs present therapeutic challenges.
Purpose of the Study:
- To summarize current medical treatment strategies for SI-NETs.
- To emphasize the need for a tailored, multidisciplinary approach.
Main Methods:
- Review of current medical treatment strategies for SI-NETs.
- Expert commentary on advanced SI-NET management.
Main Results:
- Advanced SI-NET management necessitates a case-by-case, multidisciplinary strategy.
- Integration of surgical, medical, and targeted molecular therapies is crucial.
Conclusions:
- Optimal treatment sequencing, timing, and patient selection require further investigation.
- Controlled clinical trials are needed to refine treatment protocols for advanced SI-NETs.
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