Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

Inborn Errors of Metabolism

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

"I was suicidal"-the consultant psychiatrist opening up the conversation on postnatal depression.

BMJ (Clinical research ed.)·2025

Same author

Why I . . . teach piano.

BMJ (Clinical research ed.)·2025

Same author

Why I . . . quilt.

BMJ (Clinical research ed.)·2025

Same author

Why I . . . write crosswords.

BMJ (Clinical research ed.)·2025

Same author

Paying it forward: the consultant psychiatrist.

BMJ (Clinical research ed.)·2025

Same author

Medical apprenticeships: what next now that the scheme has been paused?

BMJ (Clinical research ed.)·2025

Search research articles

Related Experiment Video

Updated: Mar 18, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Neonatal jaundice.

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)

|June 30, 2016

Summary

This summary is machine-generated.

Jaundice is a common condition in newborns caused by high bilirubin levels. While usually harmless, prompt identification of potentially harmful high bilirubin levels is crucial.

More Related Videos

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

Related Experiment Videos

Last Updated: Mar 18, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

Area of Science:

Neonatal Medicine
Pediatrics
Clinical Biochemistry

Background:

Jaundice is a frequent condition in newborns, affecting approximately 60% of infants.
Premature infants exhibit higher incidences of jaundice.
The condition arises from elevated bilirubin levels in the blood.

Purpose of the Study:

To outline the essential facts regarding neonatal jaundice.
To emphasize the importance of monitoring bilirubin levels in newborns.

Main Methods:

This summary is based on established clinical knowledge and epidemiological data regarding neonatal jaundice.
Information is synthesized from pediatric and neonatal medical literature.

Main Results:

Neonatal jaundice is characterized by increased blood bilirubin.
Most cases are benign and resolve spontaneously within two weeks.
A subset of cases involves dangerously high bilirubin levels requiring medical intervention.

Conclusions:

Early detection and management of neonatal jaundice are vital.
Prompt identification of elevated bilirubin levels is necessary to prevent potential harm.