Related Experiment Video
Updated: Mar 18, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
EETs and HO-1 cross-talk
David Sacerdoti1, Paola Pesce1, Marco Di Pascoli1
1Department of Medicine, University of Padova, Padova, Italy.
Abstract:
Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation and function, promote angiogenesis and organ regeneration, oppose oxidative stress and inflammation, improve diabetes and obesity, have protective effects on the liver, and participate in portal hypertension. Furthermore, EETs induce HO-1, and inhibition of HO-1 abolishes most of the effects of EETs. Thus, a close interaction between the two systems exists, and is relevant in view of their therapeutic potential.
Related Concept Videos
Oxygen Transport in the Blood
Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Peroxisomes
Regulation of Angiogenesis and Blood Supply
Respiration and Gaseous Exchange
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves...
Cooperative Allosteric Transitions

