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Updated: Jan 25, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Physiological role for amyloid precursor protein in adult experience-dependent plasticity
Sally A Marik1, Olav Olsen2, Marc Tessier-Lavigne1
1Laboratory of Neurobiology, The Rockefeller University, New York, NY 10065;
Abstract:
Changes in neural circuits after experience-dependent plasticity are brought about by the formation of new circuits via axonal growth and pruning. Here, using a combination of electrophysiology, adeno-associated virus-delivered fluorescent proteins, analysis of mutant mice, and two-photon microscopy, we follow long-range horizontally projecting axons in primary somatosensory cortex before and after selective whisker plucking. Whisker plucking induces axonal growth and pruning of horizontal projecting axons from neurons located in the surrounding intact whisker representations. We report that amyloid precursor protein is crucial for axonal pruning and contributes in a cell autonomous way.
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