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Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban

Yosuke Miwa1, Toshinori Minamishima1, Toshiaki Sato1

  • 1Department of Cardiology, Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

Journal of Arrhythmia
|June 30, 2016
PubMed

The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fibrinogenolysis system among these oral anticoagulants. Here, we report a case of persistent AF, in whom apixaban, factor Xa inhibitor resolved an LAA clot refractory to warfarin and direct thrombin inhibition. Factor Xa inhibitor, apixaban, could resolve the left appendage thrombosis refractory to warfarin and dabigatran.

Keywords:
Atrial fibrillationDirect thrombin inhibitorFactor Xa inhibitorLeft atrial appendage thrombus

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