Elevated 99mTc-MDP and 18F-NaF Uptake in a Bladder Stone.

Area of Science:

• Nuclear medicine
• Radiology
• Oncology

Background:

• Addison disease and osteoporosis are chronic conditions requiring careful monitoring.
• Imaging plays a crucial role in diagnosing and managing various pathologies.

Observation:

• An 82-year-old male patient presented with known Addison disease, osteoporosis, and a soft tissue mass.
• The patient underwent Technetium-99m methylene diphosphonate (Tc-MDP) bone scintigraphy with SPECT/CT and Fluorine-18 sodium fluoride (F-NaF) PET/CT.

Findings:

• Both Tc-MDP bone scintigraphy and F-NaF PET/CT demonstrated unexpected elevated radiotracer uptake within a bladder stone.
• This finding was incidental to the evaluation of the soft tissue mass and bone disease.

Implications:

• This case highlights the potential for incidental findings of radiotracer accumulation in bladder calculi.
• Further investigation may be warranted to understand the mechanism of F-NaF and Tc-MDP uptake in bladder stones.
• Consideration of bladder stones in the differential diagnosis for abnormal pelvic uptake in bone imaging studies is suggested.