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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
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Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes
Jie Pan1, Bethany I Harriss2, Chi-Fai Chan1
1Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
Abstract:
A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. (68)GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.
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