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Updated: Mar 18, 2026
05:46
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
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Recent Advances on Nitric Oxide in the Upper Airways
Mauro Maniscalco1, Andrea Bianco, Gennaro Mazzarella
1Largo delle Mimose, 1, 80131 Napoli, Italy.
Current Medicinal Chemistry
|July 1, 2016
Summary
Exhaled nitric oxide (NO) from the upper airways plays key roles in bodily functions and disease. This review explores NO
Area of Science:
- Respiratory Medicine
- Physiology
- Immunology
Background:
- Exhaled nitric oxide (NO) is produced in the upper airways.
- Nitric oxide is crucial for physiological processes like vasoregulation, neurotransmission, and respiration.
- NO also participates in protective and defense mechanisms, as well as pathological processes.
Purpose of the Study:
- To review current research on the origin, biology, and significance of NO in the upper respiratory tract.
- To discuss the role of nasal and paranasal sinus-derived NO in inflammatory conditions.
Main Methods:
- Literature review of ongoing investigations.
- Synthesis of existing data on nitric oxide's role in upper airway physiology and pathology.
Main Results:
- Nitric oxide (NO) is integral to upper airway function, impacting regulation, defense, and disease.
- NO derived from nasal and paranasal sinuses is implicated in inflammatory airway disorders.
Conclusions:
- Understanding the source and function of exhaled NO is vital for respiratory health.
- Further research into NO's role in conditions like allergic rhinitis, sinusitis, PCD, and CF is warranted.
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