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Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics

Jennifer D Black, Khosrow Rezvani1

  • 1Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, 414 E. Clark Street, Lee Medical Building, Vermillion, SD 57069, USA. khosrow.rezvani@usd.edu.

Current Medicinal Chemistry
|July 1, 2016
PubMed
Abstract

Insights

Targeting heat shock protein 70 (HSP70) family members, particularly mortalin-2, shows promise for colorectal cancer (CRC) treatment. Inhibiting mortalin-2 may enhance chemotherapy effectiveness and improve patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Targeted therapies offer improved chemotherapy response with fewer side effects.
  • Heat shock protein 70 (HSP70) family members are explored as therapeutic targets in colorectal cancer (CRC).

Purpose of the Study:

  • To review current and future molecular therapies for CRC.
  • To assess the potential of HSP70 family members in advancing CRC drug design and discovery.

Main Methods:

  • Literature review focusing on significant and translational contributions.
  • Analysis of current clinical and investigational CRC targeted agents.
  • Examination of HSP70 family's tumorigenic functions, specifically mortalin-2.

Main Results:

  • Current targeted agents and novel investigational therapies for CRC are discussed.
  • Mortalin-2, crucial for mitochondrial biogenesis, acts as an oncoprotein in colon cancer.
  • Mortalin-2 inhibition is identified as a potential strategy to enhance patient response to chemotherapy.

Conclusions:

  • Further research into HSP70 family's role in CRC is needed.
  • Translating molecular insights into targeted therapies can improve clinical outcomes.
  • Targeting HSP70 family members may offer therapeutic synergy with cytotoxic agents.

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