Related Experiment Video
Updated: Mar 18, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Synthesis and Bioactivity of (R)-Ricinoleic Acid Derivatives: A Review
1Institute of General Food Chemistry, Faculty of Biotechnology and Food Science, Lodz University of Technology; ul. Stefanowskiego 4/10, 90-924 Lodz, Poland. jozef.kula@p.lodz.pl.
Abstract:
(R)-Ricinoleic acid (RA) [(12R,9Z)-hydroxyoctadecenoic acid], the main compound of castor seed oil, because of its unusual structure readily undergoes multi-directional chemical and biochemical transformations to produce derivatives with the retained carbon skeleton or with its degradation. Many of these are of high biological activity, as documented by an in vitro study, and possess therapeutic potential. This review article provides an overview of the recent developments in the area of synthesis of RA based compounds with anticancer and antimicrobial activities. Moreover, the antiinflammatory and analgesic properties of some ricinoleic acid derivatives are also highlighted.
More Related Videos
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
Relative Reactivity of Carboxylic Acid Derivatives
A key factor in assessing the reactivity of the acid derivatives is the basicity of the substituent or the leaving group. The lower the basicity of the leaving group, the higher the reactivity of the derivative. The basicity of the leaving group follows this order:
Halide ions < Acyloxy ions < Alkoxy ions < Amine ions
α-Hydroxy Ketones via Reductive Coupling of Esters: Acyloin Condensation Overview
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis