Related Experiment Video
Updated: Mar 18, 2026
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
2.3K
Precision medicine in cardiology.
Elliott M Antman1, Joseph Loscalzo2
1Brigham and Women's Hospital, TIMI Study Group, 350 Longwood Avenue, Office Level One, Boston, Massachusetts 02115, USA.
Nature Reviews. Cardiology
|July 1, 2016
Summary
Precision medicine offers a new era for cardiovascular research, integrating diverse data to improve individual and population health. This approach empowers patients as active participants in their care, moving beyond traditional disease silos.
Area of Science:
- Cardiovascular Medicine
- Genomics
- Public Health
Background:
- Noncommunicable diseases are a leading cause of death globally.
- Current medical approaches often remain siloed, limiting comprehensive understanding of disease.
- Precision medicine offers a transformative framework for cardiovascular health.
Purpose of the Study:
- To outline the potential of precision medicine in cardiovascular research and clinical practice.
- To identify necessary tools and data types for implementing precision cardiovascular medicine.
- To address challenges and propose a future vision for integrated cardiovascular healthcare.
Main Methods:
- Integration of multi-omic data, exposome, social determinants, microbiome, behavioral data, and electronic health records.
- Leveraging existing cardiovascular expertise to drive discovery science and clinical research efficiency.
- Addressing technical and sociopolitical barriers to precision medicine implementation.
Main Results:
- Precision medicine requires novel tools to characterize individual and population cardiovascular health.
- Cardiovascular specialists can enhance research and clinical efficiency through precision approaches.
- Implementation necessitates overcoming technical and sociopolitical hurdles.
Conclusions:
- Precision medicine can revolutionize cardiovascular health by providing more accurate insights for individuals and populations.
- Active patient participation and shared decision-making are central to the precision healthcare model.
- Moving beyond siloed medicine towards a universal precision medicine environment is essential for future health advancements.
Related Concept Videos
01:29Cardiomyopathy V: Interprofessional Care
591
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
591
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
636
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
636
01:30Cardiomyopathy II: Dilated Cardiomyopathy
725
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
725
01:29Pharmacogenomics: Identification of New Drug Targets
73
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
73
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
02:50Combination Therapies and Personalized Medicine
1.7K
1.7K