Childbirth after surgery for familial adenomatous polyposis in Japan
Hirotoshi Kobayashi1,2, Hideyuki Ishida3,4, Hideki Ueno3,5
1Department of Surgery, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan. h-kobayashi.srg2@tmd.ac.jp.
Purpose:
Familial adenomatous polyposis (FAP) is a genetic disorder. Some female patients with FAP can become pregnant. However, the current state of childbirth after surgery for FAP is unclear in Japan.
Methods:
The study investigated 303 patients (147 female) who had undergone surgery for FAP at the 23 institutions between 2000 and 2012.
Results:
Eighty female patients had information available on childbirth after surgery for FAP. Eight patients (10 %) gave birth after surgery. The mean age at surgery for FAP was 27 (range 20-41) years and 37 years in patients with and without childbirth after surgery, respectively (P = 0.044). The rate of childbirth after surgery was 17 % in women ≤30 years of age and 13 % in those ≤40 years of age. Although only one patient with invasive cancer (2.9 %) gave childbirth after surgery, seven patients without cancer (15.6 %) gave birth (P = 0.045).
Conclusions:
This study clarified the current state of childbirth after surgery for FAP in Japan. It is important to use these data to determine the best therapeutic approach for female FAP patients.
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