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Insights into Campylobacter jejuni colonization and enteritis using a novel infant rabbit model
Yuwei Shang1, Fangzhe Ren1, Zhaojun Song1
1Jiangsu Key Lab of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Scientific Reports
|July 1, 2016
Summary
Researchers developed a new infant rabbit model to study Campylobacter jejuni infections. This model reveals key aspects of the pathogen
Area of Science:
- Microbiology
- Infectious Diseases
- Animal Models
Background:
- Campylobacter jejuni is a common enteric pathogen.
- A lack of suitable disease models hinders research into C. jejuni.
Purpose of the Study:
- To establish and validate an infant rabbit model for C. jejuni infection.
- To elucidate previously unknown features of C. jejuni pathogenesis.
Main Methods:
- Infection of infant rabbits with C. jejuni.
- Assessment of systemic invasion, diarrheal symptoms, and intestinal colonization.
- Analysis of cytokine induction and gene expression during infection.
Main Results:
- The infant rabbit model demonstrated systemic C. jejuni invasion and diarrhea mimicking human campylobacteriosis.
- The large intestine was the primary site of colonization and showed inflammation with cytokine induction.
- Genes including acs, cj1385, and cj0259 were identified as potentially involved in C. jejuni invasion.
Conclusions:
- The infant rabbit serves as a viable experimental model for studying diarrheagenic Campylobacter species.
- This model will aid in understanding C. jejuni pathogenesis and related pathogens.
