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Related Experiment Video

Updated: Mar 18, 2026

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Hollow hydroxyapatite microsphere: a promising carrier for bone tissue engineering.

Hui Yang1, Huichang Gao2, Yingjun Wang2

  • 1a School of Materials Science and Engineering, Jiangxi University of Science and Technology , Ganzhou , PR China.

Journal of Microencapsulation
|July 1, 2016
PubMed
Summary

Hydroxyapatite microspheres effectively deliver alendronate for bone repair. These carriers show high drug loading and sustained release, promoting stem cell proliferation and bone formation.

Keywords:
Hydroxyapatitealendronatedrug deliverymesoporousosteogenesis

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Hydroxyapatite (HA) is a key component of bone.
  • Developing effective drug delivery systems for bone regeneration is crucial.
  • Mesoporous materials offer advantages for drug loading and release.

Purpose of the Study:

  • To synthesize and characterize hydroxyapatite (HA) microspheres with ordered mesoporous and hollow structures.
  • To evaluate the drug loading and release capabilities of HA microspheres using alendronate (AL) as a model drug.
  • To assess the biocompatibility and osteogenic potential of AL-loaded HA microspheres in mesenchymal stem cells (MSCs).

Main Methods:

  • Hydrothermal synthesis of HA microspheres using citrate as a templating agent.
  • Drug loading studies with alendronate (AL).
  • In vitro drug release studies.
  • Co-culture of HA and AL-loaded HA (HA-AL) microspheres with MSCs to evaluate cell proliferation and osteogenic differentiation.

Main Results:

  • Successfully synthesized HA microspheres with abundant ordered mesoporous and large hollow structures.
  • Achieved high AL-loading capability (46.8 wt%) and sustained drug release profile without burst release.
  • Observed initial proliferation inhibition, followed by enhanced MSC proliferation and osteogenic differentiation promoted by HA-AL compared to HA and control groups.
  • Demonstrated enhanced expression of typical osteogenic markers.

Conclusions:

  • HA microspheres are promising carriers for bone repair applications due to their favorable drug delivery characteristics.
  • The developed HA microspheres facilitate osteogenic differentiation and promote bone formation.
  • This study highlights the potential of tailored HA nanostructures for regenerative medicine and drug delivery.