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Melonoside A: An ω-Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae
Alla G Guzii1, Tatyana N Makarieva1, Vladimir A Denisenko1
1G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
Abstract:
Melonoside A (1), the first representative of a new class of ω-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge Melonanchora kobjakovae. The structure of 1, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 induces autophagy of human cisplatin-resistant germinal tumor cells NCCIT-R.
