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Comparison of Feeding Strategies for Infants With Hypoplastic Left Heart Syndrome: A Randomized Controlled Trial
Nicole T Spillane1, Sudha Kashyap2, David Bateman2
1Department of Pediatrics, Hackensack UMC, Rutgers University New Jersey Medical School, Hackensack, NJ, USA nspillane@hackensackumc.org.
Insights
Continuous enteral feedings did not significantly improve weight gain in infants with hypoplastic left heart syndrome after stage 1 procedures. Growth failure remains a concern, necessitating further research into improved feeding strategies for these infants.
Area of Science:
- Pediatric Cardiology
- Neonatal Nutrition
- Congenital Heart Disease
Background:
- Infants with hypoplastic left heart syndrome (HLHS) often experience growth failure post-stage 1 palliation.
- The impact of continuous enteral nutrition on weight gain in these infants is not well-established.
Purpose of the Study:
- To investigate the effect of continuous enteral feedings versus intermittent feedings on weight gain and nutritional status in infants with HLHS after stage 1 procedures.
Main Methods:
- A randomized controlled trial compared continuous and intermittent feeding regimens with exclusive intermittent feeding.
- Anthropometric measures and nutritional markers were assessed until hospital discharge.
- Twenty-six infants with HLHS and single ventricle variants were included.
Main Results:
- No significant differences in weight gain (24.3 vs 23.6 g/d) or weight-for-age Z scores (-1.37 vs -1.2) were observed between the feeding groups.
- Both groups achieved target daily weight gain after initiating full enteral feeds.
Conclusions:
- Continuous enteral feeding strategies did not show a significant advantage over intermittent feedings for weight gain in HLHS infants post-stage 1 palliation.
- Despite achieving target weight gain, overall growth failure persists.
- Novel strategies are required to enhance growth during initial hospitalization for infants with HLHS.
Introduction:
Infants with hypoplastic left heart syndrome are at risk for growth failure, particularly after stage 1 procedures. The effect of continuous enteral feedings on weight gain has not been previously investigated.
Methods:
A randomized controlled trial was performed in infants with hypoplastic left heart syndrome and single ventricle variants after stage 1 procedures. Eligible infants were randomized to a continuous and intermittent feeding regimen or an exclusive intermittent feeding regimen after stage 1 procedures and continued until hospital discharge. Anthropometric measures and markers of nutritional status were assessed throughout hospitalization.
Results:
Twenty-six infants completed the study. There were no significant differences in weight gain, growth, or nutritional status. Weight gain on full enteral feedings was 24.3 versus 23.6 g/d (P = .88) for the combination (continuous and intermittent) versus intermittent feeding groups. Weight-for-age Z scores at discharge were -1.37 versus -1.2 (P = .59) for the combination versus intermittent groups.
Conclusions:
No significant differences in weight gain, growth, or nutritional status were observed at hospital discharge between the two feeding strategies. Despite both groups achieving target daily weight gain after attaining full feeds, growth failure continued to be a problem after stage 1 procedures. Further strategies to improve growth during initial hospitalization are needed.
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