Comparison of Feeding Strategies for Infants With Hypoplastic Left Heart Syndrome: A Randomized Controlled Trial

Nicole T Spillane1, Sudha Kashyap2, David Bateman2

  • 1Department of Pediatrics, Hackensack UMC, Rutgers University New Jersey Medical School, Hackensack, NJ, USA nspillane@hackensackumc.org.

Insights

Continuous enteral feedings did not significantly improve weight gain in infants with hypoplastic left heart syndrome after stage 1 procedures. Growth failure remains a concern, necessitating further research into improved feeding strategies for these infants.

Area of Science:

  • Pediatric Cardiology
  • Neonatal Nutrition
  • Congenital Heart Disease

Background:

  • Infants with hypoplastic left heart syndrome (HLHS) often experience growth failure post-stage 1 palliation.
  • The impact of continuous enteral nutrition on weight gain in these infants is not well-established.

Purpose of the Study:

  • To investigate the effect of continuous enteral feedings versus intermittent feedings on weight gain and nutritional status in infants with HLHS after stage 1 procedures.

Main Methods:

  • A randomized controlled trial compared continuous and intermittent feeding regimens with exclusive intermittent feeding.
  • Anthropometric measures and nutritional markers were assessed until hospital discharge.
  • Twenty-six infants with HLHS and single ventricle variants were included.

Main Results:

  • No significant differences in weight gain (24.3 vs 23.6 g/d) or weight-for-age Z scores (-1.37 vs -1.2) were observed between the feeding groups.
  • Both groups achieved target daily weight gain after initiating full enteral feeds.

Conclusions:

  • Continuous enteral feeding strategies did not show a significant advantage over intermittent feedings for weight gain in HLHS infants post-stage 1 palliation.
  • Despite achieving target weight gain, overall growth failure persists.
  • Novel strategies are required to enhance growth during initial hospitalization for infants with HLHS.
Abstract

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