Related Experiment Video
Updated: Mar 18, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme
Mingpan Cheng1, Yinghao Li1, Jun Zhou2
1State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. canli@dicp.ac.cn and University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.
Abstract:
Enantioselective sulfoxidation reaction is achieved for the first time by a DNA metalloenzyme assembled with the human telomeric G-quadruplex DNA and Cu(ii)-4,4'-bimethyl-2,2'-bipyridine complex, and the mixed G-quadruplex architectures are responsible for the catalytic enantioselectivity and activity.
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