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H-type hypertension is an important risk factor of carotid atherosclerotic plaques

Zhilai Chen1, Fan Wang2, Yansong Zheng1

  • 1a Health Management Institute , The General Hospital of Chinese People's Liberation Army , Beijing , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 1, 2016
PubMed

Insights

H-type hypertension, characterized by high homocysteine (Hcy) levels, significantly increases the risk of carotid atherosclerotic plaques. Managing H-type hypertension and Hcy is crucial for preventing plaques and stroke.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Atherosclerosis Studies

Background:

  • H-type hypertension, defined by elevated homocysteine (Hcy) levels, is prevalent in certain populations.
  • Carotid atherosclerotic plaques are a significant risk factor for cerebrovascular events.

Purpose of the Study:

  • To investigate the association between H-type hypertension and the presence of carotid atherosclerotic plaques.
  • To determine if H-type hypertension independently predicts carotid atherosclerosis.

Main Methods:

  • A large, hospital-based study involving 13,192 Chinese patients.
  • Subjects were categorized into four groups: H-type hypertension, isolated systolic hypertension, isolated Hcy, and a control group.
  • Univariate logistic regression analysis was employed to assess the association.

Main Results:

  • H-type hypertension was present in 26.86% of subjects, with 49.31% having carotid atherosclerotic plaques.
  • The prevalence of carotid atherosclerotic plaques was significantly higher in the H-type hypertension group compared to other groups.
  • H-type hypertension was associated with a 1.63 times higher incidence of carotid atherosclerotic plaques than isolated systolic hypertension.

Conclusions:

  • H-type hypertension is an independent risk factor for developing carotid atherosclerotic plaques.
  • Interventions targeting H-type hypertension and high Hcy levels are recommended to reduce the incidence of carotid atherosclerotic plaques and stroke.
Abstract

Keywords:
Carotid atherosclerotic plaquesH-type hypertensionhealth practice managementrisk factors

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