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Visual fields of monocularly deprived macaque monkeys.

J R Wilson1, K A Lavallee, M V Joosse

  • 1Department of Anatomy and Cell Biology, Emory University, Atlanta, GA 30322.

Behavioural Brain Research
|May 1, 1989
PubMed
Summary

Monocular deprivation in macaque monkeys impacts vision based on when it starts, how long it lasts, and the method used. These findings inform our understanding of visual development and binocular competition.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Primate Research

Background:

  • Postnatal monocular deprivation is a critical period for visual system development.
  • Understanding its effects is crucial for treating visual impairments.

Purpose of the Study:

  • To investigate the impact of varying monocular deprivation parameters on visual function in macaque monkeys.
  • To explore the relationship between deprivation timing, duration, and type with visual field deficits.

Main Methods:

  • Behavioral perimetry field testing was used in macaque monkeys.
  • Three deprivation methods were employed: early eyelid suture, late eyelid suture, and long-term contact lens occlusion.
  • Deprivation varied in onset (days/months postnatally) and duration (months to years).

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Main Results:

  • Early suture (Group 1) showed normal response levels but reduced visual field extent.
  • Late suture (Group 2) resulted in reduced response levels without visual field extent changes.
  • Long-term occlusion (Group 3) led to complete or partial visual field response loss, depending on onset and duration.

Conclusions:

  • The effects of monocular deprivation are significantly influenced by the start, length, and type of deprivation.
  • Results support a binocular competition model with a nasal-to-temporal gradient.
  • An independent mechanism is proposed to explain response loss in monocular visual segments.