Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radical radiotherapy in prostatic carcinoma.

I Nilsson1, C E Lindholm, T Landberg

  • 1Department of Oncology/Radiotherapy, University Hospital, Malmö, Sweden.

Acta Oncologica (Stockholm, Sweden)
|January 1, 1989
PubMed
Summary

Radical radiotherapy for advanced prostate cancer showed limited long-term survival. Poorly differentiated tumors and extracapsular spread significantly impacted outcomes for patients with prostatic carcinoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the Comment on "Long-term effects of vacuum extraction on pelvic floor function: a cohort study in primipara".

International urogynecology journal·2016
Same author

Prebiotic preferences of human lactobacilli strains in co-culture with bifidobacteria and antimicrobial activity against Clostridium difficile.

Journal of applied microbiology·2015
Same author

Differences in activities of daily living (ADL) abilities of children across world regions: a validity study of the assessment of motor and process skills.

Child: care, health and development·2014
Same author

An attempt to work rehabilitation after long sick-leave.

Work (Reading, Mass.)·2014
Same author

Immobilized cells in microbial nitrate reduction.

Applied biochemistry and biotechnology·2013
Same author

Occupational engagement among community dwelling older people: A time-geographic perspective†.

Health promotion international·2013

Area of Science:

  • Oncology
  • Radiotherapy
  • Urologic Oncology

Background:

  • Prostate cancer, particularly poorly differentiated types, presents a significant therapeutic challenge.
  • Radical radiotherapy is a treatment modality for localized and locally advanced prostate cancer.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of radical radiotherapy in elderly patients with advanced prostatic carcinoma.
  • To assess survival rates and recurrence patterns following radiotherapy for clinical stages B, C, and D prostate cancer.

Main Methods:

  • A cohort of 111 elderly patients with prostatic carcinoma (stages B-D) received radical radiotherapy to the prostate, bladder, and lymph nodes between 1978-1986.
  • Actuarial analysis was used to determine local recurrence, distant metastases, and survival rates over an 8-year follow-up period.

Related Experiment Videos

Main Results:

  • 72% of patients experienced local recurrence or distant metastases.
  • The projected 8-year survival rate was 25%, significantly lower than the 65% expected for the general male population.
  • A 'cure' rate of approximately 49% was observed after 3 years, with survival differing significantly based on intracapsular versus extracapsular tumor extent.

Conclusions:

  • Radical radiotherapy for advanced, poorly differentiated prostate cancer in elderly patients yields modest survival figures.
  • Tumor differentiation and local extension (intracapsular vs. extracapsular) are critical prognostic factors influencing survival outcomes.
  • The findings underscore the aggressive nature of poorly differentiated prostatic carcinoma and the limitations of radiotherapy in achieving long-term cures in these cases.