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Four-Component Reaction for the Synthesis of Dithiocarbamates Starting from Cyclic Imines
Torben Schlüter1, Azim Ziyaei Halimehjani2, Daniel Wachtendorf1
1Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
Abstract:
An efficient one-pot, four-component reaction for the synthesis of dithiocarbamates using carbon disulfide, cyclic imines, acid chlorides, and commercially available primary or secondary amines has been developed by performing an acid chloride addition to a heterocyclic imine followed by subsequent nucleophilic substitution of in situ generated dithiocarbamic acid. With the aid of the newly developed and powerful multicomponent reaction, a direct route for the synthesis of 24 unknown dithiocarbamates in moderate to good yield under mild conditions is enabled.
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