Related Experiment Video
Updated: Mar 18, 2026
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
Published on: September 28, 2019
Dietary Inflammatory Index and Risk of Multiple Sclerosis in a Case-Control Study from Iran
Nitin Shivappa1, James R Hebert, Maryam Behrooz
1Department of Epidemiology and Biostatistics, Arnold School of Public Health, Columbia, S.C., USA.
Background:
Diet and inflammation have been suggested to be important risk factors for multiple sclerosis (MS).
Objectives:
In this study, we examined the ability of the dietary inflammatory index (DII) to predict MS in a case-control study conducted in Iran.
Methods:
This study included 68 MS cases and 140 controls hospitalized for acute non-neoplastic diseases. The DII was computed based on dietary intake assessed by a previously validated food frequency questionnaire. Logistic regression models were used to estimate ORs adjusted for age, energy, sex, body mass index, season of birth, rubella history, history of routine exercise before MS, smoking and history of consumption of cow's milk in the first 2 years of life.
Results:
Subjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher risk of MS, with the DII being used both as a continuous variable (ORcontinuous 1.66; 95% CI 1.19-2.31; 1 unit increase corresponding to ≈15% of its range in the current study) and a categorical variable (ORDII (>1.43 vs.≤1.43) 2.68; 95% CI 1.15-6.26).
Conclusions:
These results indicate that a pro-inflammatory diet is associated with increased risk of MS.
Insights
A pro-inflammatory diet, measured by the dietary inflammatory index (DII), is linked to an increased risk of developing multiple sclerosis (MS). Higher DII scores indicate a greater risk for MS development.
Area of Science:
- Nutrition Science
- Epidemiology
- Neurology
Background:
- Diet and inflammation are recognized as potential risk factors for multiple sclerosis (MS).
- Understanding the relationship between dietary patterns and MS risk is crucial for public health.
- Previous research suggests a link, but further investigation is warranted.
Purpose of the Study:
- To evaluate the predictive ability of the dietary inflammatory index (DII) for multiple sclerosis (MS) risk.
- To investigate the association between a pro-inflammatory diet and MS in a case-control study.
- To provide evidence on dietary factors influencing MS susceptibility.
Main Methods:
- A case-control study was conducted in Iran with 68 MS cases and 140 controls.
- Dietary intake was assessed using a validated food frequency questionnaire to compute the DII.
- Logistic regression models, adjusted for various covariates, were employed to analyze the data.
Main Results:
- Individuals with higher DII scores (indicating a more pro-inflammatory diet) exhibited a significantly increased risk of MS.
- The DII showed a positive association with MS risk when analyzed as both a continuous and categorical variable.
- A 1-unit increase in DII corresponded to an approximate 15% increase in MS risk.
Conclusions:
- A pro-inflammatory diet is associated with an elevated risk of developing multiple sclerosis.
- Dietary modification may play a role in MS prevention strategies.
- Further research can explore specific dietary components contributing to MS risk.
More Related Videos
07:43Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion
Published on: February 22, 2013
07:26Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat
Published on: February 16, 2013