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Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Related Experiment Video

Updated: Mar 18, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

Engineering and Assembly of Protein Modules into Functional Molecular Systems.

Stephan Hirschi¹, Mirko Stauffer¹, Daniel Harder¹

¹Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland.

|July 2, 2016

Summary

Synthetic biology enables creating artificial biological systems by assembling biomacromolecules and synthetic parts. This research focuses on engineering energy, transport, and catalytic modules for nanoscale molecular systems and nanofactories.

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Last Updated: Mar 18, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

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Area of Science:

Synthetic Biology
Nanotechnology
Biotechnology

Background:

Synthetic biology offers diverse approaches, from modifying organisms to building artificial systems.
Nanoscale containers with functional modules are key for healthcare, industry, and research applications.

Purpose of the Study:

To discuss the concept of assembling proteins and synthetic components into functional molecular systems.
To focus on engineering core modules: energy generation, molecular transport, and catalysis.
To explore the assembly and applications of nanoscale "nanofactories".

Main Methods:

Conceptual discussion of assembling biomacromolecules and synthetic building blocks.
Focus on engineering specific functional modules (energizing, transport, catalytic).
Exploration of approaches for creating artificial molecular systems and nanofactories.

Main Results:

Detailed discussion on engineering energizing modules for chemical energy production.
Explanation of transport modules for translocating molecules using generated energy.
Overview of catalytic modules for biochemical processing within molecular systems.

Conclusions:

The engineering of functional modules is crucial for developing advanced molecular systems.
The assembly of these modules enables the creation of artificial nanofactories.
These systems hold significant potential for biotechnology and medical health applications.