Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

324
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
324
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

248
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
248

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraductal papillary mucinous neoplasm-derived pancreatic cancer of the ventral duct in patient with pancreas divisum: a case report.

Journal of surgical case reports·2026
Same author

National utilization of minimally invasive and open liver resections.

Surgical endoscopy·2026
Same author

Trend of Adjuvant Radiation in Resected Pancreatic Ductal Adenocarcinoma: Evaluation of RTOG 0848 with a Large National Database.

Journal of gastrointestinal cancer·2026
Same author

From First Job to Mid-Career: Navigating the Unexpected Turns.

The American surgeon·2026
Same author

Efficacy and acceptability of bowel preparation strategies for inflammatory bowel disease colonoscopy: Systematic review and meta-analysis.

Endoscopy international open·2026
Same author

Optimizing Palliative Cancer Surgery Trial Completion: Lessons Learned From Qualitative Content Analysis of S1316 - Comparative Effectiveness Trial for Malignant Bowel Obstruction.

The American journal of hospice & palliative care·2025

Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

3.8K

Complication timing impacts 30-d mortality after hepatectomy.

Neda Amini1, Georgios A Margonis1, Yuhree Kim1

  • 1Division of Surgical Oncology, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland.

The Journal of Surgical Research
|July 2, 2016
PubMed
Summary

Complications after liver surgery (hepatectomy) that occur after discharge increase the risk of 30-day mortality threefold. Monitoring patients post-discharge is crucial for improving outcomes following hepatectomy.

Keywords:
HepatectomyMortalityPostoperative complicationsReoperation

More Related Videos

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.5K
Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

2.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

3.8K
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.5K
Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

2.9K

Area of Science:

  • Hepatobiliary surgery
  • Surgical outcomes research
  • Patient safety

Background:

  • Timing of post-hepatectomy complications and their impact on patient outcomes remain understudied.
  • Previous research has not specifically analyzed the relationship between complication timing and 30-day mortality after liver resection.

Purpose of the Study:

  • To investigate the association between the timing of complications (predischarge vs. postdischarge) and 30-day mortality following hepatectomy.
  • To identify specific complications that frequently occur after discharge and their impact on survival.

Main Methods:

  • Analysis of 3064 patients undergoing hepatectomy in 2014 using the American College of Surgeons National Surgical Quality Improvement Program database.
  • Cox regression analysis was employed to assess the relationship between complication timing and 30-day mortality, adjusting for confounding factors.

Main Results:

  • Postdischarge complications occurred in 16.6% of patients experiencing complications, with wound disruption and surgical site infections being common.
  • Organ space surgical site infections occurred later in minimally invasive surgery patients (16 days) compared to open surgery (10 days).
  • Postdischarge complications were associated with a nearly threefold increased risk of 30-day mortality (Hazard Ratio 2.96, P=0.04).

Conclusions:

  • While less frequent than predischarge complications, postdischarge complications significantly elevate the risk of mortality after hepatectomy.
  • The findings underscore the importance of vigilant post-discharge surveillance to mitigate risks and improve survival rates in liver surgery patients.