Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.2K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.2K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

743
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
743
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.3K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.3K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.9K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.9K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

19.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.6K
Master Transcription Regulators02:23

Master Transcription Regulators

8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence Detection Scores in Screening Mammography for Early Breast Cancer Alerts.

Radiology·2026
Same author

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.

Nature communications·2026
Same author

Understanding ischemia in children with tuberculous meningitis (iThemba): a protocol paper.

BMC pediatrics·2026
Same author

Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.

JCI insight·2026
Same author

Population-based study of pharmacogenetics and pharmacokinetics in Southern African patients with multidrug-resistant tuberculosis (PoPG): a protocol for the Namibian cohort.

BMJ open·2026
Same author

Recovering the pre-colonial population structure of Khoe-San descendant populations.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Mar 18, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA
09:39

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA

Published on: July 15, 2011

27.9K

Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis.

Nicholas Bowker1, Muneeb Salie1, Haiko Schurz1

  • 1SA MRC Centre for TB Research, DST/NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Teaching Building, 4th Floor, Room 4036, Tygerberg, Cape Town, 7505, South Africa.

Lung
|July 2, 2016
PubMed
Summary

Genetic variations in the CLEC4E gene, which encodes Mincle, were studied for their link to tuberculosis susceptibility. Researchers found no significant association between Mincle gene polymorphisms and tuberculosis risk in the studied population.

Keywords:
CLEC4EMincleMycobacterium tuberculosisPolymorphismSusceptibility

More Related Videos

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

8.5K
A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
10:41

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA

Published on: April 30, 2020

14.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA
09:39

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat VNTR - Fragment Length Analysis FLA

Published on: July 15, 2011

27.9K
A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

8.5K
A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
10:41

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA

Published on: April 30, 2020

14.9K

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Host-pathogen interactions, particularly between Mycobacterium tuberculosis and innate immune cells, are crucial in determining tuberculosis outcomes.
  • Macrophages and dendritic cells use pattern recognition receptors to detect pathogen-associated molecular patterns, initiating immune responses.
  • The mycobacterial virulence factor trehalose-6',6-dimycolate is recognized by Mincle, activating the Syk-Card9 signaling pathway in macrophages.

Purpose of the Study:

  • To investigate the role of polymorphisms in the CLEC4E gene, which encodes Mincle, in susceptibility to tuberculosis.
  • To assess whether specific single nucleotide polymorphisms (SNPs) in CLEC4E are associated with an increased or decreased risk of developing tuberculosis.

Main Methods:

  • Genotyping of four tagging single nucleotide polymorphisms (SNPs) in the CLEC4E gene (rs10841845, rs10841847, rs10841856, and rs4620776) using TaqMan® SNP assays.
  • Analysis of genetic data from 416 tuberculosis cases and 405 healthy controls.
  • Statistical analysis using logistic regression models to determine associations between SNPs and tuberculosis susceptibility.

Main Results:

  • No statistically significant association was found between any of the four genotyped CLEC4E SNPs and tuberculosis susceptibility.
  • The study did not identify a genetic link between Mincle recognition of mycobacterial glycolipids and tuberculosis disease risk through the investigated polymorphisms.

Conclusions:

  • The complexity of tuberculosis pathogenesis is highlighted, suggesting that genetic associations with key recognition proteins may not be straightforward.
  • Further research is needed to fully elucidate the genetic factors influencing tuberculosis susceptibility, as simple associations with Mincle polymorphisms were not observed.