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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Related Experiment Video

Updated: Mar 18, 2026

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
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Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

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Fat, Stem Cells, and Platelet-Rich Plasma.

Isaac B James1, Sydney R Coleman2, J Peter Rubin3

  • 1Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

Clinics in Plastic Surgery
|July 2, 2016
PubMed
Summary

Autologous fat grafting is an ideal filler for aesthetic surgery, offering natural results with minimal risk. This review examines its technical aspects and the emerging evidence for stem cell and platelet-rich plasma (PRP) therapies in facial rejuvenation.

Keywords:
Adipose-derived stem cellsAutologous fatColeman techniqueFacial augmentationFacial rejuvenationFatFat graftingLipoaspiratePRPPlatelet-rich plasmaRegenerative medicineStem cellsStromal vascular fractionStructural fat grafting

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Aesthetic Dermatology

Background:

  • Autologous fat grafting is a well-established technique for facial rejuvenation.
  • Ideal aesthetic fillers should be cost-effective, safe, and provide natural, long-lasting results.
  • Recent advancements include the integration of stem cells and platelet-rich plasma (PRP) into fat grafting procedures.

Purpose of the Study:

  • To review the technical considerations for autologous fat transfer in facial rejuvenation.
  • To explore the current evidence supporting the use of stem cells and PRP in aesthetic practices.
  • To provide a comprehensive overview of these advanced fat grafting techniques.

Main Methods:

  • Literature review of scientific articles and clinical studies.
  • Analysis of technical aspects of facial fat grafting.
  • Evaluation of evidence for stem cell and PRP augmentation in aesthetic surgery.

Main Results:

  • Autologous fat grafts demonstrate excellent outcomes, meeting most criteria for an ideal aesthetic filler.
  • Stem cell and PRP therapies show promise in enhancing fat graft survival and improving aesthetic results.
  • Further research is needed to fully elucidate the benefits and standardize protocols for these adjunct therapies.

Conclusions:

  • Autologous fat grafting remains a highly effective and safe method for facial rejuvenation.
  • Stem cells and PRP represent promising adjuncts to autologous fat grafting, potentially improving outcomes.
  • Continued investigation into regenerative approaches will refine current aesthetic surgical practices.