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The effect of amygdala kindled seizures on locus coeruleus activity
C A Jimenez-Rivera1, G K Weiss
1Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87131.
Brain Research Bulletin
|April 1, 1989
Abstract:
Locus coeruleus (LC) neuronal activity was recorded in anesthetized and in awake behaving rats during the production of amygdala afterdischarges (AD's) using kindling protocol. Both LC multiple and single unit discharges were temporally correlated with the appearance of AD's in the amygdala. Seizures were manifested in single unit activity as significant increases in firing rate. In awake animals, a bursting pattern of discharges was observed. We postulate that the observed changes in the LC activity pattern may have a modulatory role in the development of kindled seizures.