Obsessive compulsive personality disorder in Progressive Supranuclear Palsy, Multiple System Atrophy and Essential...

Area of Science:

• Neuroscience
• Psychiatry
• Neurology

Background:

• Obsessive Compulsive Personality Disorder (OCPeD) is a personality disorder characterized by rigidity and perfectionism.
• Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), and Essential Tremor (ET) are neurodegenerative disorders affecting the central nervous system.

Purpose of the Study:

• To investigate the prevalence of OCPeD in patients with MSA, PSP, and ET.
• To compare OCPeD rates in these patient groups with healthy controls.

Main Methods:

• Patients diagnosed with MSA, PSP, and ET, along with healthy controls, were enrolled.
• The Structured Clinical Interview for Personality Disorders-II (SCID-II) and psychiatric interviews were used to diagnose OCPeD.
• Cognitively impaired patients were excluded.

Main Results:

• OCPeD was diagnosed in 35.7% of PSP patients, 13.3% of MSA patients, 12.5% of ET patients, and 10% of controls.
• A low frequency of OCPeD was observed in MSA and ET patients, similar to controls.
• A higher frequency of OCPeD was found in PSP patients compared to other groups.

Conclusions:

• PSP patients exhibit a higher prevalence of OCPeD, comparable to Parkinson's Disease (PD).
• This finding suggests potential involvement of common basal ganglia networks, possibly including orbito-frontal circuits, in PSP.
• OCPeD appears less frequently in MSA and ET patients, similar to healthy individuals.