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Counterfeit Adderall Containing Aceclofenac from Internet Pharmacies.

Maria Cristina Gaudiano1, Anna Borioni1, Eleonora Antoniella1

  • 1Dipartimento del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

Journal of Forensic Sciences
|July 2, 2016
PubMed
Summary

Illegal Adderall tablets were found to contain the anti-inflammatory drug aceclofenac. This study used liquid chromatography-mass spectrometry and nuclear magnetic resonance to identify and quantify the drug, ensuring user safety.

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Area of Science:

  • Analytical Chemistry
  • Forensic Chemistry

Background:

  • Illicit drug manufacturing poses significant public health risks.
  • Accurate identification and quantification of active pharmaceutical ingredients in counterfeit medications are crucial for regulatory and safety purposes.

Observation:

  • A nontargeted liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-MS Q-TOF) approach coupled with nuclear magnetic resonance (NMR) was employed.
  • Specific mass-to-charge ratios (m/z = 354.030 and 376.012) and MS/MS fragmentation patterns were observed.
  • Accurate mass data yielded the molecular formula C16H13Cl2NO4, suggesting aceclofenac.

Findings:

  • The anti-inflammatory drug aceclofenac was rapidly identified and quantified in counterfeit Adderall tablets.
  • NMR experiments unambiguously confirmed the structure of aceclofenac.
Keywords:
Adderallaceclofenaccounterfeit medicineforensic sciencemass spectrometrynuclear magnetic resonance

Related Experiment Videos

  • Quantitative NMR determined an aceclofenac content of 90 mg/tablet with 2% relative standard deviation.

    • Implications:

    • This analytical methodology enables the precise characterization of illicit substances.
    • Findings are vital for legal proceedings, assessing user safety risks, and informing targeted analytical strategies for control laboratories.
    • Ensures accurate drug analysis for public health protection.