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Carotid atherosclerosis is associated with left ventricular diastolic function

Masahiko Harada1, Satoshi Tabako2

  • 1Department of Clinical Functional Physiology, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Oota-ku, Tokyo, 143-8541, Japan. mharada@med.toho-u.ac.jp.

Journal of Echocardiography
|July 2, 2016
PubMed

Insights

Decreased early diastolic mitral annular velocity (e') is linked to severe carotid atherosclerosis. This suggests that significant carotid atherosclerosis may contribute to left ventricular diastolic dysfunction.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Carotid intima-media thickness (IMT) is a known risk factor for stroke and cardiovascular disease.
  • Echocardiography and carotid ultrasonography are key diagnostic tools in cardiovascular assessment.

Purpose of the Study:

  • To investigate the relationship between echocardiographic findings and carotid atherosclerosis.
  • To determine if specific echocardiographic parameters correlate with carotid intima-media thickness (IMT) and plaque score (PS).

Main Methods:

  • 234 patients underwent echocardiography to assess left ventricular (LV) function, including LV ejection fraction, E/A ratio, and peak early diastolic mitral annular velocity (e').
  • Carotid ultrasonography measured maximum IMT (Max-IMT) and plaque score (PS) within one month of echocardiography.
  • Statistical analysis, including multiple logistic stepwise regression, was performed to identify associations.

Main Results:

  • A strong correlation was found between Max-IMT and PS (r=0.83, p<0.0001).
  • Decreased E/A and mitral e' indicated LV diastolic dysfunction.
  • Mitral e' was independently associated with severe carotid atherosclerosis (Max-IMT ≥ 2.8 mm or PS ≥ 10.1).

Conclusions:

  • Reduced early diastolic mitral annular velocity (e') is associated with parameters reflecting carotid atherosclerosis.
  • Severe carotid atherosclerosis may be a contributing factor to left ventricular diastolic dysfunction.
Abstract

Keywords:
Carotid atherosclerosisCarotid intima-media thicknessEchocardiographyLeft ventricular diastolic functionPlaque score

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