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A Preclinical Model of Exertional Heat Stroke in Mice
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Extreme Hyperpyrexia of Uncertain Origin.

Nikita T Shah1, Yordanos A Habtegebriel1, Dennis A Bloomfield1

  • 1Richmond University Medical Center, Staten Island, New York.

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|July 2, 2016
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Summary

This case report details an unprecedented extreme hyperpyrexia exceeding 106.7°F in a paraplegic patient. This finding challenges current fever definitions and highlights a potentially fatal condition.

Keywords:
UTIhyperprexiamalignant hyperthermiatraumatic spinal cord injury

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Area of Science:

  • Internal Medicine
  • Emergency Medicine
  • Neurology

Background:

  • Current definitions of hyperpyrexia are limited to temperatures of 106.7°F.
  • The literature describes insidious onset hyperpyrexia from various causes.
  • Rapid temperature ascent above 106.7°F has not been previously reported or evaluated.

Observation:

  • A young paraplegic patient presented with extreme hyperpyrexia.
  • The patient had multiple medical conditions, none known to cause fever.
  • The recorded temperature represents the highest in contemporary medical literature.

Findings:

  • The patient experienced a rapid, extreme hyperpyrexia.
  • The etiology of this extreme temperature elevation remains unclear.
  • This case represents a potentially fatal hyperpyrexic event.

Implications:

  • Emergency physicians must consider extreme hyperpyrexia beyond current definitions.
  • Unexplained high fevers can obscure diagnoses and lead to unnecessary evaluations.
  • This case highlights the need for further investigation into the mechanisms and management of extreme hyperpyrexia.