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Optical biosensors
Pavel Damborský1, Juraj Švitel2, Jaroslav Katrlík3
1Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia.
Essays in Biochemistry
|July 2, 2016
Summary
Optical biosensors, widely used in bioanalysis, offer sensitive detection of various analytes. This review classifies and describes principles of surface plasmon resonance (SPR) and other optical biosensor types.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Optics
Background:
- Optical biosensors are prevalent tools for detecting biological and chemical substances.
- Understanding their principles and applications is crucial for advancements in diagnostics and research.
Purpose of the Study:
- To classify optical biosensors and describe their operational principles.
- To highlight the bioanalytical applications of various optical biosensor systems.
- To focus on surface plasmon resonance (SPR)-based biosensors.
Main Methods:
- Classification of optical biosensor types.
- Description of underlying principles of operation.
- Review of bioanalytical applications.
Main Results:
- Surface plasmon resonance (SPR) biosensors, including SPR imaging and localized SPR, are the most common.
- Other systems discussed: evanescent wave fluorescence, bioluminescent optical fibre, interferometric, ellipsometric, reflectometric interference spectroscopy, and surface-enhanced Raman scattering biosensors.
- These biosensors enable sensitive and selective detection of diverse analytes.
Conclusions:
- Optical biosensors provide versatile platforms for detecting a wide range of analytes.
- SPR-based biosensors are a key technology in this field.
- The described optical biosensor systems have significant bioanalytical potential.
