Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

5
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
5

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Luminescent mesoporous bioactive glass nanoparticles: Samarium-doping for enhanced bone regeneration, antibacterial activity, and bioimaging.

Biomaterials advances·2026
Same author

Microfluidic toolbox using padlock probes and rolling circle amplification for direct detection and genotyping of viral RNA.

RSC advances·2026
Same author

Persistent Sensory, Motor and Functional Difficulties From Childhood to Adolescence in Developmental Coordination Disorder.

Journal of autism and developmental disorders·2026
Same author

Development of single chain antibodies for targeting Ewing sarcoma surface marker CD99.

Biochemical and biophysical research communications·2026
Same author

Integrated strategy for breast cancer biomarker analysis using dual ionic liquid aqueous biphasic systems and microfluidic immunoassays.

Lab on a chip·2026
Same author

Ionic-liquid-based aqueous biphasic systems meet microfluidics: from antibodies to aptamers in prostate-specific antigen detection.

Analytica chimica acta·2026

Related Experiment Video

Updated: Mar 18, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K

Lab-on-chip systems for integrated bioanalyses.

João Pedro Conde1, Narayanan Madaboosi2, Ruben R G Soares2

  • 1Instituto de Engenharia de Sistemas E Computadores-Microsistemas e Nanotecnologias (INESC MN) and IN-Institute of Nanoscience and Nanotechnology, Rua Alves Redol, 9, 1000-029 Lisbon, Portugal Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisbon, Portugal joao.conde@tecnico.ulisboa.pt.

Essays in Biochemistry
|July 2, 2016
PubMed
Summary
This summary is machine-generated.

Lab-on-chip systems integrate microfluidics for

Keywords:
fluidic handlingintegrated systemslab-on-chipmicrofluidicspoint-of-caresignal detection

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

15.6K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

13.7K

Related Experiment Videos

Last Updated: Mar 18, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K
A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

15.6K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

13.7K

Area of Science:

  • Biomolecular detection systems
  • Microfluidics
  • Lab-on-chip technology

Background:

  • Microfluidics enables miniaturized lab-on-chip (LOC) systems for 'sample-to-answer' analysis.
  • These systems process raw biological, food, or environmental samples for analyte assessment.
  • Integration of multiple operational stages is crucial for LOC device functionality.

Purpose of the Study:

  • To review the essential stages involved in developing integrated 'sample-to-answer' microfluidic systems.
  • To discuss the requirements for achieving sensitive, rapid, and cost-effective analyte detection at the point-of-care/use.

Main Methods:

  • Discussion of fluidic handling for precise liquid transport.
  • Overview of molecular recognition for specific analyte capture.
  • Examination of transduction, sample preparation, and signal amplification techniques.

Main Results:

  • Successful 'sample-to-answer' systems require seamless integration of fluidic handling, molecular recognition, and transduction.
  • Upstream sample preparation and signal amplification are key for enhancing sensitivity.
  • The review outlines the critical components for developing advanced LOC devices.

Conclusions:

  • Effective integration of all stages is paramount for realizing point-of-care/use LOC devices.
  • Achieving relevant sensitivity, speed, and cost targets is essential for practical application.
  • This review provides a framework for understanding the development of comprehensive biomolecular detection systems.