Modulation of cis-dichlorodiammineplatinum(II)-induced cytotoxicity by benzaldehyde derivatives

The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution with electron-releasing groups, i.e. -CH3 and -OH, adjacent to the aldehyde moiety increased the protective effect relative to benzaldehyde. Electron-withdrawing, or bulky, substituents reduced the protective effect. Protection from cell inactivation by cis-DDP coincided with an aldehyde-mediated reduction in platinum accumulation.