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Related Experiment Video

Updated: Mar 18, 2026

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
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PENETRATING KERATOPLASTY IN HIGH RISK CASES.

D P Vats1, J Parihar2, F Rodrigues2

  • 1Senior Advisor (Ophthalmology), Command Hospital (Western Command), Chandimandir.

Medical Journal, Armed Forces India
|July 2, 2016
PubMed
Summary

Penetrating keratoplasty outcomes improve in high-risk patients with careful management. However, chemical injuries and dry eyes remain challenging indications for corneal transplantation.

Keywords:
Concurrent proceduresGraft clarityPenetrating keratoplasty, RegraftingTriple procedureVascularized corneaVisual outcome

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Area of Science:

  • Ophthalmology
  • Transplantation Surgery

Background:

  • Penetrating keratoplasty (PK) in high-risk cases presents significant challenges.
  • Poor outcomes are common in pediatric patients, pseudophakic bullous keratopathy, and vascularized corneas.

Purpose of the Study:

  • To evaluate the outcomes of penetrating keratoplasty in high-risk patient populations.
  • To identify factors influencing success and failure in these challenging cases.

Main Methods:

  • A retrospective analysis of 101 patients undergoing PK for high-risk indications.
  • Concurrent procedures included PC IOL implantation and vitrectomy.
  • Follow-up ranged from six months to four years.

Main Results:

  • Gratifying results were achieved with good donor material, intraoperative handling, and postoperative care.
  • Concurrent procedures were performed in some cases.
  • Chemical injuries and dry eyes showed poor prognosis.

Conclusions:

  • Meticulous surgical technique and postoperative management are crucial for successful high-risk PK.
  • Corneal transplantation remains unrewarding for patients with chemical injuries or dry eyes.