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Related Experiment Videos

Syphilitic proctitis.

Juliana F Yang1, Lan Peng1, Ali A Siddiqui1

  • 1Division of Digestive and Liver Disease (Yang, Mayorga) and the Department of Pathology (Peng), the University of Texas Southwestern Medical Center, Dallas, Texas; and the Division of Digestive and Liver Disease, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (Siddiqui).

Proceedings (Baylor University. Medical Center)
|July 2, 2016
PubMed
Summary

Syphilitic proctitis, a rare rectal infection, can mimic cancer and is hard to diagnose. Early detection via biopsy and treatment with penicillin led to successful patient recovery.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Proctology

Background:

  • Syphilitic proctitis is an uncommon condition often presenting with non-specific symptoms.
  • The lack of pathognomonic signs complicates diagnosis, potentially leading to misdiagnosis and inappropriate treatment.
  • Differential diagnosis of rectal masses includes infections, inflammatory conditions, and malignancies.

Observation:

  • A 31-year-old male presented with a rectal mass clinically resembling a tumor.
  • The mass involved the rectal and sigmoid colon walls, exhibiting ulcerated characteristics.
  • Diagnostic challenges were noted due to the atypical presentation.

Findings:

  • Biopsy of the rectal mass revealed the presence of Treponema pallidum organisms.

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  • The findings were consistent with a diagnosis of syphilitic proctitis.
  • Microscopic examination confirmed the causative agent of syphilis.

    • Implications:

    • This case highlights the importance of considering syphilis in the differential diagnosis of rectal masses.
    • Prompt diagnosis through biopsy is crucial for effective management of syphilitic proctitis.
    • Intravenous benzyl penicillin demonstrated efficacy in treating this rare condition, leading to clinical improvement.