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UP1306, a Botanical Composition with Analgesic and Anti-inflammatory Effect
Mesfin Yimam1, Young-Chul Lee2, Ping Jiao1
1Unigen, Inc., 3005 1 Ave., Seattle, WA 98121, USA.
Pharmacognosy Research
|July 2, 2016
Summary
UP1306, a natural anti-inflammatory and analgesic agent, effectively reduced arthritis symptoms in animal models. This botanical blend shows dual cyclooxygenase and lipoxygenase inhibition, offering a safer alternative to NSAIDs for arthritis pain management.
Area of Science:
- Pharmacology and Natural Product Research
- Inflammation and Pain Management
Background:
- Arthritis pain is a primary symptom of inflammation, often managed with NSAIDs that carry significant side effects.
- There is a need for safer, evidence-based natural alternatives for arthritis symptom relief.
Purpose of the Study:
- To evaluate the anti-inflammatory and analgesic effects of UP1306, a botanical composition.
- To assess the dual cyclooxygenase (COX) and lipoxygenase (LOX) inhibition activity of UP1306.
Main Methods:
- UP1306, a blend of Acacia catechu and Morus alba extracts, was tested in carrageenan-induced rat paw edema and mouse writhing assays.
- In vitro COX and LOX inhibition assays were performed to determine IC50 values.
Main Results:
- UP1306 significantly reduced pain and edema in animal models, comparable to ibuprofen at higher doses.
- In vitro studies showed dose-dependent inhibition of COX-1, COX-2, and 5'-LO by UP1306.
Conclusions:
- UP1306 exhibits dual COX-LO inhibition, demonstrating analgesic and anti-inflammatory properties.
- This botanical agent shows potential as a dietary supplement for managing arthritis symptoms.
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