Related Experiment Video
Updated: Mar 18, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance
Chao Li1, Xiaofen Ma2, Mengshi Dong2
1Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People's Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, Guangzhou, People's Republic of China.
Objective:
Investigating functional specialization is crucial for a complete understanding of the neural mechanisms of primary insomnia (PI). Resting-state functional magnetic resonance imaging (fMRI) is a useful tool to explore the functional specialization of PI. However, only a few studies have focused on the functional specialization of PI using resting-state fMRI and results of these studies were far from consistent. Thus, the current study aimed to investigate functional specialization of PI using resting-state fMRI with amplitude of low frequency fluctuations (ALFFs) algorithm.
Methods:
In this study, 55 PI patients and 44 healthy controls were included. ALFF values were compared between the two groups using two-sample t-test. The relationship of abnormal ALFF values with clinical characteristics and duration of insomnia was investigated using Pearson's correlation analysis.
Results:
PI patients showed lower ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, right middle frontal gyrus, left inferior parietal lobule, and bilateral cerebellum posterior lobes, while higher ALFF values in the right middle/inferior temporal that extended to the right occipital lobe. In addition, we found that the duration of PI negatively correlated with ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, and the Pittsburgh Sleep Quality Index score negatively correlated with ALFF values in the left inferior parietal lobule.
Conclusion:
The present study added information to limited studies on functional specialization and provided evidence for hyperarousal hypothesis in PI.
More Related Videos
07:56Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
Published on: June 24, 2025
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
Related Concept Videos
Brain Imaging
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
Insomnia
Multiple factors contribute...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge: