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Primary intracranial lymphomas
Shagufta T Mufti1, Saleh S Baeesa2, Jaudah A Al-Maghrabi3
1Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Asian Journal of Neurosurgery
|July 2, 2016
Summary
Primary CNS lymphoma (PCNSL) predominantly affects middle-aged women, often presenting in the frontal lobe. Diffuse large B-cell lymphoma is the most common subtype in this patient population.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary CNS lymphoma (PCNSL) is a rare, aggressive non-Hodgkin's lymphoma (NHL) with increasing incidence.
- It affects both immunocompromised and immunocompetent individuals and carries a poor prognosis.
Purpose of the Study:
- To characterize the clinico-pathological, immunohistochemical, and radiological features of PCNSL.
- To delineate PCNSL profiles at Jeddah to King Faisal Hospital and Research Center.
Main Methods:
- Retrospective analysis of 15 pathologically confirmed PCNSL cases.
- Data collected from July 2000 to December 2012.
- Evaluation of clinico-pathological, immunohistochemical, and radiological data.
Main Results:
- PCNSL showed a female predilection (53.3%), particularly in the 40-59 age group, with a mean age of 50.4 years.
- The frontal region was the most common location (46.6%), with 46.6% presenting as multiple intracranial masses.
- All cases were Non-Hodgkin B-cell lymphomas, predominantly diffuse large B-cell lymphoma (86.6%), expressing CD45 and CD20.
Conclusions:
- PCNSL typically affects middle-aged and older adults with a female predominance.
- The frontal lobe is the most frequent site, and diffuse large B-cell lymphoma is the predominant subtype.
