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Fascicular Visual Field Defects in Open-Angle Glaucoma: Evaluation with Microperimetry.

Loredana Arrico1, Rossella Giannotti1, Manuela Fratipietro1

  • 1Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.

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Summary

Microperimetry (Mp-1) accurately correlates with Humphrey perimetry for evaluating visual field defects in primary open-angle glaucoma (POAG) patients. This aids in better monitoring and modulating glaucoma therapy.

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Area of Science:

  • Ophthalmology
  • Visual Electrophysiology
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Accurate assessment of visual field defects is crucial for managing POAG.
  • Microperimetry offers potential for detailed functional evaluation.

Purpose of the Study:

  • To evaluate the accuracy of microperimetry (Mp-1) in patients with POAG and visual field defects.
  • To correlate Mp-1 results with standard Humphrey perimetry (30-2 program).
  • To assess the utility of Mp-1 for monitoring glaucomatous damage.

Main Methods:

  • 40 eyes from 25 POAG patients with perimetric defects were studied.
  • Microperimetry (Nidek Mp-1) and Humphrey 30-2 perimetry were performed.
  • Pearson's correlation and Bland-Altman analysis were used for data analysis.

Main Results:

  • Mean sensitivity values from Mp-1 showed significant correlation with Humphrey 30-2 perimetry (r=0.556).
  • Interpolated mean sensitivity values were 11.98 dB (SD 4.31) for Mp-1 and 17.95 dB (SD 4.32) for Humphrey perimetry.
  • Microperimetry provided topographic visualization of reduced sensitivity areas.

Conclusions:

  • Microperimetry (Mp-1) is a valuable tool for assessing visual field defects in POAG.
  • Its topographic visualization aids in targeted retesting and monitoring.
  • Improved monitoring allows for better modulation of glaucoma therapy and management of functional deficits.