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Comparative testis proteome dataset between cattleyak and yak.

Fang Yang1, TserangDonko Mipam2, Lei Sun3

  • 1College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.

Data in Brief
|July 2, 2016
PubMed
Summary

Male cattleyak hybrids are infertile due to spermatogenic arrest. This study identified differentially expressed proteins in cattleyak testes, revealing molecular insights into male infertility in these unique cattle-yak hybrids.

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Area of Science:

  • Animal breeding and genetics
  • Proteomics
  • Reproductive biology

Background:

  • Cattleyak, a hybrid of cattle and yak, possess valuable economic traits and adaptability to high altitudes.
  • However, male cattleyak exhibit infertility, characterized by spermatogenic arrest, limiting their practical application.
  • Understanding the molecular basis of this infertility is crucial for effective utilization of cattleyak.

Purpose of the Study:

  • To identify and analyze differentially expressed proteins (DEPs) in the testes of male cattleyak compared to yak.
  • To elucidate the proteomic differences associated with spermatogenic arrest in cattleyak.
  • To provide a dataset for further research into the molecular mechanisms of cattleyak male infertility.

Main Methods:

  • Testis tissues from cattleyak and yak were analyzed using high-performance liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS).
  • Proteomic data was processed to identify differentially expressed proteins (DEPs).
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed for functional and pathway annotation of DEPs.

Main Results:

  • A significant number of DEPs were identified between cattleyak and yak testes.
  • Functional classification and pathway analysis revealed alterations in proteins related to spermatogenesis and cellular processes in infertile cattleyak.
  • Specific protein candidates associated with spermatogenic arrest were highlighted.

Conclusions:

  • Proteomic analysis provides critical insights into the molecular underpinnings of male infertility in cattleyak.
  • The identified DEPs offer potential targets for understanding and possibly addressing spermatogenic arrest.
  • This comparative proteomic dataset advances the study of reproductive incompatibilities in hybrid animals.