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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Two dimensional, electronic particle tracking in liquids with a graphene-based magnetic sensor array.

Rodrigo F Neumann1, Michael Engel2, Mathias Steiner1

  • 1IBM Research, Av. Pasteur 138 & 146, Urca, Rio de Janeiro, 22290-240, Brazil. rneumann@br.ibm.com.

Nanoscale
|July 2, 2016
PubMed
Summary
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We developed a novel graphene-based sensor array for tracking magnetic nanoparticles in liquids. This Magnetic Nanoparticle Velocimetry technique offers high-accuracy flow analysis in opaque media.

Area of Science:

  • Physics
  • Chemistry
  • Biology
  • Nanotechnology

Background:

  • Nanoscale liquid flow is crucial in various scientific fields.
  • Current methods for flow analysis can be limited, especially in opaque media.

Purpose of the Study:

  • To introduce a new method and device for spatially resolving nanoscale liquid flow.
  • To enable accurate tracking of magnetic nanoparticles in liquids.

Main Methods:

  • Integration of an array of graphene-based magnetic (Hall) sensors.
  • Numerical simulation of sensor performance for tracking magnetic nanoparticles.
  • Development of the Magnetic Nanoparticle Velocimetry (MNV) technique.

Main Results:

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  • Accurate detection of individual magnetic nanoparticles.
  • Reconstruction of nanoparticle trajectories with sub-pixel precision.
  • Demonstration of MNV's capability for time-resolved flow analysis.

Conclusions:

  • The developed device enables precise nanoscale flow measurement.
  • The MNV technique provides a non-optical alternative for particle tracking.
  • Potential applications in lab-on-chip devices for opaque media analysis.