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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Natural Polyphenols in Cancer Chemoresistance

Saad A Hussain1, Amal A Sulaiman1, Curt Balch2

  • 1a Department of Pharmacology and Toxicology , College of Pharmacy, University of Baghdad , Baghdad , Iraq.

Nutrition and Cancer
|July 2, 2016
PubMed

Insights

Dietary polyphenols show promise in overcoming cancer drug resistance by targeting multiple cellular mechanisms. Further research is warranted to explore their potential in augmenting chemotherapy efficacy and preventing multidrug resistance.

Area of Science:

  • Oncology
  • Pharmacology
  • Nutritional Science

Background:

  • Chemotherapy resistance is a significant obstacle in cancer treatment.
  • Mechanisms include altered signaling, tumor microenvironment changes, and drug efflux.
  • Dietary polyphenols are linked to reduced cancer risk due to antioxidant and anti-cancer properties.

Purpose of the Study:

  • To review the role of natural polyphenolic compounds in overcoming diverse cancer drug resistance mechanisms.
  • To explore how polyphenols inhibit key resistance pathways.
  • To highlight the potential of polyphenols in enhancing chemotherapy.

Main Methods:

  • Literature review of studies on dietary polyphenols and cancer drug resistance.
  • Analysis of molecular and cellular mechanisms targeted by polyphenols.
  • Examination of epidemiological data correlating polyphenol intake with cancer risk.

Main Results:

  • Polyphenols exhibit antioxidant capacity and inhibit procarcinogen activation, proliferation, metastasis, and angiogenesis.
  • They can inhibit or downregulate active drug efflux transporters, crucial in multidrug resistance.
  • Polyphenols induce apoptosis and modulate immune and inflammatory responses.

Conclusions:

  • Dietary polyphenols offer a promising natural strategy to combat cancer drug resistance.
  • Their multifaceted actions on various resistance mechanisms warrant further investigation for clinical application.
  • Understanding the crosstalk between signaling and metabolism in cancer can guide polyphenol-based therapies.

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