Related Experiment Video

Updated: Mar 18, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

750

Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter

Murat Haliloglu1, Beliz Bilgili, Ozlem Haliloglu

  • 1Marmara University School of Medicine, Istanbul, Turkey. mrt.haliloglu@gmail.com.

Journal of Infection in Developing Countries
|July 2, 2016
PubMed
Abstract

Insights

Severe vitamin D deficiency is linked to worse outcomes in patients with ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumanii. Lower vitamin D levels may predict mortality in these critical care patients.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Endocrinology

Background:

  • Vitamin D is crucial for host defense and impacts mortality in intensive care unit (ICU) patients.
  • Extensively drug-resistant Acinetobacter baumanii (XDR A. baumanii) poses a significant threat, particularly in ventilator-associated pneumonia (VAP).

Purpose of the Study:

  • To investigate the association between vitamin D levels and mortality predictors in patients with XDR A. baumanii VAP.
  • To determine if vitamin D levels can serve as a prognostic indicator for VAP outcomes.

Main Methods:

  • A retrospective study included adult ICU patients diagnosed with VAP caused by XDR A. baumanii.
  • Collected data included 25-hydroxyvitamin D [25(OH)D] levels, procalcitonin (PCT), C-reactive protein (CRP), n-terminal pro-BNP (NT-proBNP), and clinical scores (SOFA, APACHE II, CPIS).

Main Results:

  • All 44 patients exhibited vitamin D deficiency.
  • Higher 28-day mortality was observed in patients with 25(OH)D levels ≤ 10 ng/mL (p = 0.001).
  • Lower vitamin D levels correlated with higher SOFA scores and PCT levels, and negative correlations were found between clinical scores/biomarkers and 25(OH)D levels.

Conclusions:

  • Severe vitamin D deficiency is associated with adverse outcomes in XDR A. baumanii VAP.
  • Vitamin D levels show potential as a prognostic predictor for VAP.
  • Further research is warranted to assess the impact of vitamin D repletion on mortality in these patients.

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.6K

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
619
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.1K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
3.9K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.4K
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
1.1K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.2K