Related Experiment Video

Updated: Mar 18, 2026

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

5.3K

Vascular endothelial growth factor polymorphism (-460 T/C) is related to hypertension-associated chronic kidney

Anna Małkiewicz1, Jolanta Myśliwska1, Maria Skrzypkowska1

  • 1a Department of Immunology , Medical University of Gdańsk , Gdańsk , Poland.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 2, 2016
PubMed

Insights

The vascular endothelial growth factor (VEGF) -460 TT genotype is linked to higher immature endothelial progenitor cells (EPCs) and worse kidney function in hypertensive patients. This suggests a potential predisposition to hypertension-related chronic kidney disease.

Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Genetics

Background:

  • Endothelial progenitor cells (EPCs) play a crucial role in vascular health.
  • The vascular endothelial growth factor (VEGF) -460 C/T polymorphism is associated with various cardiovascular conditions.
  • Hypertension is a major risk factor for chronic kidney disease (CKD).

Purpose of the Study:

  • To characterize EPCs in normotensive and hypertensive individuals with the VEGF -460 C/T polymorphism.
  • To investigate if this polymorphism predisposes to hypertension-related CKD.

Main Methods:

  • Genotyping for VEGF -460 C/T polymorphism.
  • Flow cytometry to analyze EPC phenotypes (CD34+, CD34+CD45dim, CD34+CD133+CD45dim).
  • Assessment of renal function parameters: estimated glomerular filtration rate (eGFR), creatinine, and blood urea nitrogen (BUN).

Main Results:

  • Hypertensive patients with the TT genotype exhibited significantly higher levels of immature EPCs with specific phenotypes.
  • The TT genotype group showed significantly lower eGFR and higher creatinine and BUN levels compared to other genotypes.
  • These findings suggest a correlation between the VEGF -460 TT genotype and impaired renal function in hypertensive individuals.

Conclusions:

  • The VEGF -460 TT genotype may be associated with increased mobilization of EPCs.
  • This mobilization might indicate a higher risk or severity of hypertension-related renal complications.
  • Further research is warranted to confirm the role of VEGF polymorphism in hypertension-induced CKD pathogenesis.

Keywords:
Endothelial precursorsVEGF polymorphismkidney disease

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.8K
Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
98
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.9K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
65
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.3K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1000
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K