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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Novel Disease-Drug Database Demonstrating Applicability for Pharmacogenomic-Based Prescribing
M Whirl-Carrillo1, K Sangkuhl1, L Gong1
1Department of Genetics, Stanford University, Stanford, California, USA.
Pharmacogenomics advances enable clinical decision support (CDS) tools integrated into electronic health records (EHRs). A new disease-drug association tool aids providers in selecting pharmacogenomics-informed treatments at the point of prescribing.
Area of Science:
- Clinical Informatics
- Pharmacogenomics
- Medical Decision Support
Background:
- Recent years have seen significant progress in the clinical application of pharmacogenomics.
- Tools for clinical decision support (CDS) are increasingly integrated into electronic health records (EHRs).
Purpose of the Study:
- To describe the development of a novel disease-drug association tool.
- To enhance pharmacogenomics integration at the point of care.
Main Methods:
- Creation of a disease-drug association tool.
- Enabling providers to search by disease indications.
- Integrating pharmacogenomics annotations into the prescribing workflow.
Main Results:
- A tool was developed that links diseases to potential drug treatments.
- The tool provides pharmacogenomics annotations for treatment options.
- Facilitates informed prescribing decisions based on genetic information.
Conclusions:
- The developed tool supports the clinical implementation of pharmacogenomics.
- Enhances provider ability to utilize pharmacogenomics at the point of prescribing.
- Aimed at improving patient care through personalized medicine.
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